Article
Concordance of c-kit mutational status in matched primary and metastatic cutaneous canine mast cell tumors at baseline.
Journal of veterinary internal medicine - 1 Jan 2000
Marconato L, Zorzan E, Giantin M, Di Palma S, Cancedda S, Dacasto M
Abstract excerpt
BACKGROUND: Mutation analysis of proto-oncogene c-kit (c-kit) is advisable before starting treatment with tyrosine kinase inhibitors in dogs with mast cell tumor (MCT), including those with metastatic disease. Testing is usually performed on primary tumors, assuming that c-kit mutation status does not change in metastasis. HYPOTHESIS/OBJECTIVES: To give an insight into the mutational processes and to make a...
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