Article
Concordance of c-kit mutational status in matched primary and metastatic cutaneous canine mast cell tumors at baseline.
Journal of veterinary internal medicine - 1 Jan 2000
Marconato L, Zorzan E, Giantin M, Di Palma S, Cancedda S, Dacasto M
Abstract excerpt
BACKGROUND: Mutation analysis of proto-oncogene c-kit (c-kit) is advisable before starting treatment with tyrosine kinase inhibitors in dogs with mast cell tumor (MCT), including those with metastatic disease. Testing is usually performed on primary tumors, assuming that c-kit mutation status does not change in metastasis. HYPOTHESIS/OBJECTIVES: To give an insight into the mutational processes and to make a...
Topics
- Animals
- Dog Diseases
- Dogs
- Exons
- Female
- Genetic Testing
- Genotyping Techniques
- Male
- Mast-Cell Sarcoma
- Mastocytoma
- Mutation
- Proto-Oncogene Proteins c-kit