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Article

Central roles of the roof plate in telencephalic development and holoprosencephaly.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Jul 2006

Cheng Xun, Hsu Ching-mei, Currle D Spencer, Hu Jia Sheng, Barkovich A James, Monuki Edwin S

Abstract excerpt

The roof plate is a well known signaling center in CNS development, but its roles in the developing telencephalon and the common holoprosencephaly (HPE) malformation have been uncertain. Using cellular ablations in mice, we show that roof plate cell loss causes failed midline induction and HPE in the dorsal telencephalon. This morphologic phenotype is accompanied by selective deficits in midline gene expression...

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Identifiers

PMID: 16855091
DOI: 10.1523/JNEUROSCI.0714-06.2006
PMCID: PMC6674267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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