Article
Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
Nature genetics - 1 Dec 2000
Luo G, Santoro I M, McDaniel L D, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz R A, Bradley A
Abstract excerpt
Bloom syndrome is a disorder associated with genomic instability that causes affected people to be prone to cancer. Bloom cell lines show increased sister chromatid exchange, yet are proficient in the repair of various DNA lesions. The underlying cause of this disease are mutations in a gene encoding a RECQ DNA helicase. Using embryonic stem cell technology, we have generated viable Bloom mice that are prone to a...
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