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Article

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

19 Sept 2002

Abstract excerpt

The p53 tumor suppressor gene product is a transcription factor involved in cell-cycle regulation, apoptosis, and DNA repair. We and others have shown that p53 is required for efficient nucleotide excision repair (NER) of UV-induced DNA lesions. p53-deficient cells are defective in the repair of UV photoproducts in genomic DNA but proficient for transcription-coupled repair. Therefore, we examined whether p53...

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PMID: 12242345
DOI: 10.1073/pnas.202485699

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