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Article

Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current.

Circulation research - 20 Sept 2002

Zhou Jingsong, Shin Hyeon-Gyu, Yi Jianxun, Shen Wangzhen, Williams Christine P, Murray Katherine T

Abstract excerpt

Activation of protein kinase A (PKA) increases Na+ current derived from the human cardiac Na+ channel, hH1, in a slow, nonsaturable manner. This effect is prevented by compounds that disrupt plasma membrane recycling, implying enhanced trafficking of channels to the cell membrane as the mechanism responsible for Na+ current potentiation. To investigate the molecular basis of this effect, preferred consensus sites...

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Identifiers

PMID: 12242273
DOI: 10.1161/01.res.0000033598.00903.27

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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