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Article

An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1.

Channels (Austin, Tex.) - 1 Jan 2000

Jones Heather M, Bailey Mark A, Baty Catherine J, Macgregor Gordon G, Syme Colin A, Hamilton Kirk L, Devor Daniel C

Abstract excerpt

We previously demonstrated that the ATP/PKA-dependent activation of the human intermediate conductance, Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal motif. The NH2-terminus of hIK1 contains a multi-basic 13RRRKR17 motif, known to be important in the trafficking and function of ion channels. While individual mutations within this domain have no effect on channel function, the triple mutation...

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Identifiers

PMID: 18690018
DOI: 10.4161/chan.3999
PMCID: PMC3419011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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