Article
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
Current drug targets. Cardiovascular & haematological disorders - 1 Aug 2005
Karmazyn M, Sawyer M, Fliegel L
Abstract excerpt
The Na(+)/H(+) exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher eukaryotes this integral membrane protein removes one intracellular H(+) for one extracellular Na(+) protecting cells from intracellular acidification. NHE is of essential importance in the myocardium. It prevents intracellular acidosis that inhibits contractility. NHE also plays a key role in damage to the mammalian...
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