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Article

Regulation of caveolar cardiac sodium current by a single Gsalpha histidine residue.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2008

Palygin Oleg A, Pettus Janette M, Shibata Erwin F

Abstract excerpt

Cardiac sodium channels (voltage-gated Na(+) channel subunit 1.5) reside in both the plasmalemma and membrane invaginations called caveolae. Opening of the caveolar neck permits resident channels to become functional. In cardiac myocytes, caveolar opening can be stimulated by applying beta-receptor agonists, which initiates an interaction between the stimulatory G protein subunit-alpha (G(s)alpha) and caveolin-3....

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Share to Adrenergic beta-Agonists
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Source

Identifiers

PMID: 18281377
DOI: 10.1152/ajpheart.01337.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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