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Article

Protein kinase C enhances human sodium channel hNav1.7 resurgent currents via a serine residue in the domain III-IV linker.

FEBS letters - 3 Nov 2014

Tan Zhi-Yong, Priest Birgit T, Krajewski Jeffrey L, Knopp Kelly L, Nisenbaum Eric S, Cummins Theodore R

Abstract excerpt

Resurgent sodium currents likely play a role in modulating neuronal excitability. Here we studied whether protein kinase C (PKC) activation can increase resurgent currents produced by the human sodium channel hNav1.7. We found that a PKC agonist significantly enhanced hNav1.7-mediated resurgent currents and this was prevented by PKC antagonists. The enhancing effects were replicated by two...

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Identifiers

PMID: 25240195
DOI: 10.1016/j.febslet.2014.09.011
PMCID: PMC4451938

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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