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Article

Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.

The Journal of biological chemistry - 5 Jan 2007

Engel Patti L, Kobayashi Tomoyoshi, Biesiadecki Brandon, Davis Jonathan, Tikunova Svetlana, Wu Steven, Solaro R John

Abstract excerpt

Force generating strong cross-bridges are required to fully activate cardiac thin filaments, but the molecular signaling mechanism remains unclear. Evidence demonstrating differential extents of cross-bridge-dependent activation of force, especially at acidic pH, in myofilaments in which slow skeletal troponin I (ssTnI) replaced cardiac TnI (cTnI) indicates the significance of a His in ssTnI that is an homologous...

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PMID: 17099250
DOI: 10.1074/jbc.M512337200

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Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments.PMID 17099250Read ↗

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