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Article

Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform.

The Journal of biological chemistry - 6 May 2005

Venkatraman Gayathri, Gomes Aldrin V, Kerrick W Glenn L, Potter James D

Abstract excerpt

The major goal of this study was to elucidate how troponin T (TnT) dilated cardiomyopathy (DCM) mutations in fetal TnT and fetal troponin affect the functional properties of the fetal heart that lead to infantile cardiomyopathy. The DCM mutations R141W and DeltaK210 were created in the TnT1 isoform, the primary isoform of cardiac TnT in the embryonic heart. In addition to a different TnT isoform, a different...

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Identifiers

PMID: 15623536
DOI: 10.1074/jbc.M409337200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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