Article
Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice.
Genetics - 1 Sept 2002
Campbell Patrick K, Waymire Katrina G, Heier Robb L, Sharer Catherine, Day Diane E, Reimann Heike, Jaje J Michael, Friedrich Glenn A, Burmeister Margit, Bartness Timothy J, Russell Lonnie D, Young Larry J, Zimmer Michael, Jenne Dieter E, MacGregor Grant R
Abstract excerpt
ROSA22 male mice are sterile due to a recessive gene-trap mutation that affects development of the spermatid flagellum. The defect involves the flagellar axoneme, which becomes unstable around the time of its assembly. Despite a subsequent complete failure in flagellar assembly, development of the spermatid head appears normal and the spermatid head is released at the correct stage in spermatogenesis. The...
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