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<i>Mfsd14a</i> ( <i>Hiat1</i> ) gene disruption causes globozoospermia and infertility in male mice

22 Apr 2016

Abstract excerpt

The Mfsd14a gene, previously called Hiat1, encodes a transmembrane protein of unknown function with homology to the solute carrier protein family. To study the function of the MFSD14A protein, mutant mice (Mus musculus, strain 129S6Sv/Ev) were generated with the Mfsd14a gene disrupted with a LacZ reporter gene. Homozygous mutant mice are viable and healthy, but males are sterile due to a 100-fold reduction in the...

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PMID: 27107036
DOI: 10.1530/rep-15-0557

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