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Article

A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice.

Developmental biology - 1 Jun 2009

Geyer Christopher B, Inselman Amy L, Sunman Jeffrey A, Bornstein Sheila, Handel Mary Ann, Eddy Edward M

Abstract excerpt

Males homozygous for the repro32 ENU-induced mutation produced by the Reproductive Genomics program at The Jackson Laboratory are infertile, have low epididymal sperm concentrations, and produce sperm with abnormally shaped heads and poor motility. The purpose of the present study was to identify the mutated gene in repro32 mice and to define the structural and functional changes causing infertility and the...

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Source

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Identifiers

PMID: 19341723
DOI: 10.1016/j.ydbio.2009.03.020
PMCID: PMC2688473

Genes

CAPZA3
CAPZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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