Article
A transgenic insertion causing cryptorchidism in mice.
Genesis (New York, N.Y. : 2000) - 1 May 2001
Overbeek P A, Gorlov I P, Sutherland R W, Houston J B, Harrison W R, Boettger-Tong H L, Bishop C E, Agoulnik A I
Abstract excerpt
A distinctive feature of gonadal maturation in mammals is the movement to an extraabdominal location. Testicular descent is a complex, multistage process whereby the embryonic gonads migrate from their initial abdominal position to the scrotum. Failure in this process results in cryptorchidism, a frequent congenital birth defect in humans. We report here a new mouse transgenic insertional mutation, cryptorchidism...
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