Article
Oligogenic heterozygous inheritance of sperm abnormalities in mouse.
eLife - 22 Apr 2022
Martinez Guillaume, Coutton Charles, Loeuillet Corinne, Cazin Caroline, Muroňová Jana, Boguenet Magalie, Lambert Emeline, Dhellemmes Magali, Chevalier Geneviève, Hograindleur Jean-Pascal, Vilpreux Charline, Neirijnck Yasmine, Kherraf Zine-Eddine, Escoffier Jessica, Nef Serge, Ray Pierre F, Arnoult Christophe
Abstract excerpt
Male infertility is an important health concern that is expected to have a major genetic etiology. Although high-throughput sequencing has linked gene defects to more than 50% of rare and severe sperm anomalies, less than 20% of common and moderate forms are explained. We hypothesized that this low success rate could at least be partly due to oligogenic defects - the accumulation of several rare heterozygous...
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