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Article

Constitutive activation of the LH receptor is associated with an alteration in the conformation of the ectodomain.

Molecular and cellular endocrinology - 30 Aug 2002

Jaquette Julie, Segaloff Deborah L

Abstract excerpt

The human LH receptor (hLHR) consists of a heptahelical segment prototypical of G protein-coupled receptors and a large ectodomain. The binding of hormone to the ectodomain or the presence of activating mutations stabilize the hLHR in an active conformation. Although it has been inferred that activation of the hLHR involves conformational alterations, direct evidence supporting this has not been reported. We have...

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Identifiers

PMID: 12242044
DOI: 10.1016/s0303-7207(02)00220-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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