Article
Requirement of cysteine residues in exons 1-6 of the extracellular domain of the luteinizing hormone receptor for gonadotropin binding.
The Journal of biological chemistry - 8 Mar 1996
Zhang R, Buczko E, Dufau M L
Abstract excerpt
The functional importance of cysteine residues in the extracellular domain and the extracellular loops (EL1 and EL2) to hormone binding of the rat luteinizing hormone receptor (LHR) was investigated. For this purpose, cysteines in the seven-transmembrane holoreceptor (Form A) and its hormone-bind...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Binding Sites
- Blotting, Western
- Cell Line
- Cell Membrane
- Chlorocebus aethiops
- Chorionic Gonadotropin
- Cysteine
- Exons
- Female
- Genetic Variation
- Humans
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Ovary