Article
Certain activating mutations within helix 6 of the human luteinizing hormone receptor may be explained by alterations that allow transmembrane regions to activate Gs.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1998
Abell A N, McCormick D J, Segaloff D L
Abstract excerpt
Male-limited gonadotropin-independent precocious puberty (MPP) is frequently associated with mutations of the human LH/CG receptor (hLHR) that result in constitutively active hLHRs. Many such activating mutations have been identified in transmembrane 6 of the hLHR, with the substitution of Asp-57...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Cell Line
- Cell Membrane
- Embryo, Mammalian
- GTP-Binding Protein alpha Subunits, Gs
- Humans
- Kidney
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Structure, Secondary
- Receptors, LH
- Structure-Activity Relationship