Article

Mutations in Conserved Regions of Eel Luteinizing Hormone Receptor Result in Constitutive Activation or Inactivation

2019-07-08

Abstract excerpt

Luteinizing hormone receptor (LHR) is a member of the seven-transmembrane (TM) receptor family. Several mutations in LHR have been identified in many mammalian species, leading to either constitutive activation or inactivation of the receptor. Mutations in highly conserved regions of the TM domain have been reported. In this study, we analyzed signal transduction by three constitutively active mutants (designated...

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Literature Corpus work: 1cb24ba6-e154-513a-aa34-1bff5f90dcd8
DOI: 10.20944/preprints201907.0117.v1

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