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Article

Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.

Journal of molecular biology - 1 Sept 2000

Whisstock J C, Pike R N, Jin L, Skinner R, Pei X Y, Carrell R W, Lesk A M

Abstract excerpt

Antithrombin, uniquely among plasma serpins acting as proteinase inhibitors in the control of the blood coagulation cascade, circulates in a relatively inactive form. Its activation by heparin, and specifically by a pentasaccharide core of heparin, has been shown to involve release of the peptide loop containing the reactive centre from partial insertion in the A sheet of the molecule. Here we compare the...

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Identifiers

PMID: 10966821
DOI: 10.1006/jmbi.2000.3982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin.PMID 10966821Read ↗

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