Article
Ligand-induced Conformational Alterations of the Androgen Receptor Analyzed by Limited Trypsinization
1 Nov 1995
Abstract excerpt
Limited proteolysis of in vitro produced human androgen receptor was used to probe the different conformations of the receptor after binding of androgens and several antiandrogens. The results provide evidence for five different conformations of the receptor, as detected by the formation of proteolysis resisting fragments: 1) an initial conformation of the unoccupied receptor not resisting proteolytic attack; and...
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