Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo.

Blood - 1 Oct 2002

Zhu Delin, Orchard Jennifer, Oscier David G, Wright Dennis H, Stevenson Freda K

Abstract excerpt

Tumors of the splenic marginal zone can present in spleen or blood. The maturational status of the neoplastic B cells from each site appears heterogeneous, with either unmutated or mutated variable-region heavy chain (V(H)) genes. To determine an influence of tissue location, we assessed matched blood and splenic tumor cells from 4 patients and found them identical. However, one patient with unmutated V(H) genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Lymphoma

Share to Sequence Alignment

Share to Sequence Homology, Nucleic Acid

Share to Spleen

Source

Identifiers

PMID: 12239182
DOI: 10.1182/blood-2002-01-0169

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

V(H) gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo.PMID 12239182Read ↗

Analysis of VH genes in 49 marginal zone lymphoma cases reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection.Semantic proximity Read ↗

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.Semantic proximity Read ↗

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors.Semantic proximity Read ↗

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications.Semantic proximity Read ↗

Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion.Semantic proximity Read ↗

Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course.Semantic proximity Read ↗

Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation.Semantic proximity Read ↗

Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.Semantic proximity Read ↗

Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes.Semantic proximity Read ↗

Molecular heterogeneity of splenic marginal zone lymphomas: analysis of mutations in the 5' non-coding region of the bcl-6 gene.Semantic proximity Read ↗

Splenic marginal zone lymphomas appear to originate from different B cell types.Semantic proximity Read ↗

Mutation analysis of IgVH genes in splenic marginal zone lymphomas: correlation with clinical characteristics and outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.