Article
Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion.
Blood - 1 Jan 1999
Tierens A, Delabie J, Michiels L, Vandenberghe P, De Wolf-Peeters C
Abstract excerpt
Splenic marginal-zone B cells, marginal-zone B cells of Peyer's patches in the gut, and nodal marginal-zone B cells (also identified as monocytoid B cells) share a similar morphology and immunophenotype. These cells likely represent a distinct subset of B cells in humans and rodents, but their precise ontogenetic relationship as well as their origin from B cells of the germinal center is still debated. To study...
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