Article
Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion.
Blood - 1 Jan 1999
Tierens A, Delabie J, Michiels L, Vandenberghe P, De Wolf-Peeters C
Abstract excerpt
Splenic marginal-zone B cells, marginal-zone B cells of Peyer's patches in the gut, and nodal marginal-zone B cells (also identified as monocytoid B cells) share a similar morphology and immunophenotype. These cells likely represent a distinct subset of B cells in humans and rodents, but their pr...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Cell Division
- Cell Separation
- Clone Cells
- DNA Mutational Analysis
- Dissection
- Electrophoresis, Polyacrylamide Gel
- Gene Rearrangement
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Germinal Center
- Humans
- Immunoglobulin Variable Region
- Immunohistochemistry
- Ki-67 Antigen
- Lymph Nodes
- Molecular Sequence Data