An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors.

doi:10.1158/1078-0432.CCR-15-1170

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Article

An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2016

Bikos Vasilis, Karypidou Maria, Stalika Evangelia, Baliakas Panagiotis, Xochelli Aliki, Sutton Lesley-Ann, Papadopoulos George, Agathangelidis Andreas, Papadopoulou Evdoxia, Davis Zadie, Algara Patricia, Kanellis George, Traverse-Glehen Alexandra, Mollejo Manuela, Anagnostopoulos Achilles, Ponzoni Maurilio, Gonzalez David, Pospisilova Sarka, Matutes Estella, Piris Miguel Angel, Papadaki Theodora, Ghia Paolo, Rosenquist Richard, Oscier David, Darzentas Nikos, Tzovaras Dimitrios, Belessi Chrysoula, Hadzidimitriou Anastasia, Stamatopoulos Kostas

Abstract excerpt

PURPOSE: Prompted by the extensive biases in the immunoglobulin (IG) gene repertoire of splenic marginal-zone lymphoma (SMZL), supporting antigen selection in SMZL ontogeny, we sought to investigate whether antigen involvement is also relevant post-transformation. EXPERIMENTAL DESIGN: We conducted a large-scale subcloning study of the IG rearrangements of 40 SMZL cases aimed at assessing intraclonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complementarity Determining Regions

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Lymphoma, B-Cell, Marginal Zone

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Identifiers

PMID: 26647217
DOI: 10.1158/1078-0432.CCR-15-1170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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