Article
Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer.
The Journal of biological chemistry - 16 May 2014
Jiang Xuliang, Fischer David, Chen Xiaoyan, McKenna Sean D, Liu Heli, Sriraman Venkataraman, Yu Henry N, Goutopoulos Andreas, Arkinstall Steve, He Xiaolin
Abstract excerpt
Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for reproductive indications. The FSHR extracellular domains were observed in the crystal structure as a trimer, which enabled us to propose a novel model for the receptor activation mechanism. The model predicts that FSHR binds Asnα(52)-deglycosylated FSH at a 3-fold...
Topics
- Allosteric Regulation
- Animals
- CHO Cells
- Cricetinae
- Cricetulus
- Follicle Stimulating Hormone
- Humans
- Intracellular Space
- Models, Molecular
- Mutagenesis
- Mutation
- Protein Multimerization
- Protein Structure, Quaternary