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Article

Identification of Shc docking site on Ret tyrosine kinase.

Oncogene - 20 Feb 1997

Arighi E, Alberti L, Torriti F, Ghizzoni S, Rizzetti M G, Pelicci G, Pasini B, Bongarzone I, Piutti C, Pierotti M A, Borrello M G

Abstract excerpt

The RET proto-oncogene encodes two isoforms of a receptor type tyrosine kinase which plays a role in neural crest and kidney development. Distinct germ-line mutations of RET have been associated with the inherited cancer syndromes MEN2A, MEN2B and FMTC as well as with the congenital disorder Hirschsprung disease (HSCR), whereas somatic rearrangements (RET/PTCs) have been frequently detected in the papillary...

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PMID: 9047384
DOI: 10.1038/sj.onc.1200896

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RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of Shc docking site on Ret tyrosine kinase.PMID 9047384Read ↗

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Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.Semantic proximity Read ↗

RET activation by germline MEN2A and MEN2B mutations.Semantic proximity Read ↗

Differential membrane compartmentalization of Ret by PTB-adaptor engagement.Semantic proximity Read ↗

The Shp-1 and Shp-2, tyrosine phosphatases, are recruited on cell membrane in two distinct molecular complexes including Ret oncogenes.Semantic proximity Read ↗

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