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SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer

3 Sept 2002

Abstract excerpt

The gene for the transducer of transforming growth factor-beta/bone morphogenetic protein signalling SMAD4, a potential suppressor of colorectal carcinogenesis, is located at the chromosomal region 18q21. In order to evaluate the clinical relevance of SMAD4 deletion, gene copy alterations were determined by copy dosage using real-time quantitative PCR in 202 colorectal tumour biopsies from a previous randomised...

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PMID: 12237773
DOI: 10.1038/sj.bjc.6600511

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