Article

A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer

2020-02-20

Abstract excerpt

<h4>Objective</h4> Loss of SMAD4 is associated with worse outcomes for colorectal cancer patients. We used gene ontology and bioinformatics to identify an RNA-based SMAD4-modulated profile and test its association with patient outcome. <h4>Design</h4> Using a discovery dataset of 250 colorectal cancer patients, we analyzed expression of BMP/Wnt target genes for association with SMAD4 expression. Promoters of the B...

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Literature Corpus work: 00a2ba5a-1c84-535e-9a34-32fa49083b8b
DOI: 10.1101/2020.02.16.20023663

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