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Article

SMAD7 is a prognostic marker in patients with colorectal cancer

15 Jan 2003

Abstract excerpt

Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFbeta signaling by SMADs. Following the definition of SMAD4 deletion as a negative predictive marker for chemotherapy benefit in patients with CRC, we aimed to evaluate the clinical relevance of the deletion of other...

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PMID: 12584741
DOI: 10.1002/ijc.10908

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