Fully automated three-dimensional tracking of cancer cells in collagen gels: determination of motility phenotypes at the cellular level.

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Article

Fully automated three-dimensional tracking of cancer cells in collagen gels: determination of motility phenotypes at the cellular level.

Cancer research - 15 Sept 2002

Demou Zoe N, McIntire Larry V

Abstract excerpt

We developed a fully automated three-dimensional cell tracking system that quantified the effect of extracellular matrix components on the infiltration and migration of tumor cells. The three-dimensional trajectories of two highly invasive cell lines, the human HT-1080 fibrosarcoma and the human MDA-MB-231 adenocarcinoma, were determined for long-term infiltration in plain or Matrigel-containing collagen type I...

Topics

Adenocarcinoma
Cell Movement
Collagen
Collagen Type I
Data Interpretation, Statistical
Drug Combinations
Extracellular Matrix
Fibrosarcoma
Humans
Laminin
Markov Chains
Phenotype
Proteoglycans
Tumor Cells, Cultured

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Open in PubMed

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PMID: 12235000

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