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Article

2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen

4 Jun 2012

Abstract excerpt

Growth factor-induced migration is a critical step in the dissemination and metastasis of solid tumors. Although differences in properties characterizing cell migration on two-dimensional (2D) substrata versus within three-dimensional (3D) matrices have been noted for particular growth factor stimuli, the 2D approach remains in more common use as an efficient surrogate, especially for high-throughput experiments....

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PMID: 22665521
DOI: 10.1083/jcb.201201003

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