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Article

Characterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis.

PloS one - 1 Jan 2017

Anguiano María, Castilla Carlos, Maška Martin, Ederra Cristina, Peláez Rafael, Morales Xabier, Muñoz-Arrieta Gorka, Mujika Maite, Kozubek Michal, Muñoz-Barrutia Arrate, Rouzaut Ana, Arana Sergio, Garcia-Aznar José Manuel, Ortiz-de-Solorzano Carlos

Abstract excerpt

Microfluidic devices are becoming mainstream tools to recapitulate in vitro the behavior of cells and tissues. In this study, we use microfluidic devices filled with hydrogels of mixed collagen-Matrigel composition to study the migration of lung cancer cells under different cancer invasion microenvironments. We present the design of the microfluidic device, characterize the hydrogels morphologically and...

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Source

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Identifiers

PMID: 28166248
DOI: 10.1371/journal.pone.0171417
PMCID: PMC5293277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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