Article
beta-lactamase gene promoters of 71 clinical strains of Klebsiella oxytoca.
Antimicrobial agents and chemotherapy - 1 Feb 1996
Fournier B, Lagrange P H, Philippon A
Abstract excerpt
beta-Lactamase gene promoters of 45 clinical Klebsiella oxytoca isolates resistant to beta-lactams and exhibiting beta-lactamase hyperproduction differed from those in 26 susceptible strains. Direct sequencing revealed one mutation in either the -10 or -35 conserved sequences: a G-to-A transition of the fifth base (67%) or a G-to-T transversion of the first base of the -10 sequence (27%) or a T-to-A transversion...
Topics
- Base Sequence
- Electrophoresis, Polyacrylamide Gel
- Europe
- Klebsiella
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Homology, Nucleic Acid
- United States
- beta-Lactam Resistance
- beta-Lactamases