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Article

Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence.

Journal of neuroimmunology - 1 Sept 2002

Wang Xiong-Biao, Kakoulidou Maria, Giscombe Ricardo, Qiu Qianhui, Huang DeRen, Pirskanen Ritva, Lefvert Ann Kari

Abstract excerpt

Cytolytic T lymphocyte-associated antigen-4 (CTLA-4) plays a critical role in the down-regulation of antigen-activated immune responses. The aberrant CTLA-4 expression is characterized by low surface and intracellular levels of CTLA-4 protein, impaired up-regulation of CTLA-4 in T cells in response to ConA stimulation and high levels of soluble CTLA-4 (sCTLA-4) in serum. The serum levels of sCTLA-4 are positively...

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PMID: 12225905
DOI: 10.1016/s0165-5728(02)00228-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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