Article
MacMARCKS mutation blocks macrophage phagocytosis of zymosan.
The Journal of biological chemistry - 28 Jul 1995
Zhu Z, Bao Z, Li J
Abstract excerpt
A major protein kinase C substrate, MacMARCKS (F52, MPR), was examined for its role in phagocytosis. In macrophage-phagocytosing zymosan particles, MacMARCKS was concentrated around nascent phagosomes as detected by immunofluorescent microscopy. The effector domain of MacMARCKS contains the phosp...
Topics
- Cell Adhesion Molecules
- Cell Line
- Endocytosis
- Lipoproteins, LDL
- Macrophages
- Membrane Proteins
- Mutation
- Phagocytosis
- Phagosomes
- Protein Kinase C
- Proteins
- Receptors, LDL
- Receptors, Scavenger
- Zymosan