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Article

Phosphatidic acid regulation of PIPKI is critical for actin cytoskeletal reorganization.

Journal of lipid research - 1 Dec 2012

Roach Akua N, Wang Ziqing, Wu Ping, Zhang Feng, Chan Robin B, Yonekubo Yoshiya, Di Paolo Gilbert, Gorfe Alemayehu A, Du Guangwei

Abstract excerpt

Type I phosphatidylinositol-4-phosphate 5-kinase (PIPKI) is the main enzyme generating the lipid second messenger phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], which has critical functions in many cellular processes, such as cytoskeletal reorganization, membrane trafficking, and signal transduction. All three members of the PIPKI family are activated by phosphatidic acid (PA). However, how PA regulates the...

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Identifiers

PMID: 22991193
DOI: 10.1194/jlr.M028597
PMCID: PMC3494241

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