Article
Phosphoinositides regulate membrane-dependent actin assembly by latex bead phagosomes.
Molecular biology of the cell - 1 Apr 2002
Defacque Hélène, Bos Evelyne, Garvalov Boyan, Barret Cécile, Roy Christian, Mangeat Paul, Shin Hye-Won, Rybin Vladimir, Griffiths Gareth
Abstract excerpt
Actin assembly on membrane surfaces is an elusive process in which several phosphoinositides (PIPs) have been implicated. We have reconstituted actin assembly using a defined membrane surface, the latex bead phagosome (LBP), and shown that the PI(4,5)P(2)-binding proteins ezrin and/or moesin were essential for this process (). Here, we provide several lines of evidence that both preexisting and newly synthesized...
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