Article
Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes.
Neurology - 10 Sept 2002
den Heijer T, Oudkerk M, Launer L J, van Duijn C M, Hofman A, Breteler M M B
Abstract excerpt
The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain...
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