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Article

Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype.

Neurology - 12 Jul 2000

Moffat S D, Szekely C A, Zonderman A B, Kabani N J, Resnick S M

Abstract excerpt

The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. The authors compared longitudinal rates of change in hippocampal volume as a function of APOE genotype in nondemented elderly individuals. Rate of volumetric loss was significantly greater among epsilon4+ compared with epsilon4- individuals. These results indicate that individuals positive for the APOE...

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Source

Identifiers

PMID: 10891924
DOI: 10.1212/wnl.55.1.134

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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