Article
Association of mu-opioid receptor subunit gene and idiopathic generalized epilepsy.
Neurology - 10 Sept 2002
Wilkie H, Osei-Lah A, Chioza B, Nashef L, McCormick D, Asherson P, Makoff A J
Abstract excerpt
OBJECTIVE: To replicate and extend the previously reported association between the opioid receptor mu subunit gene (OPRM1) and idiopathic absence epilepsy (IAE), using a sample of 230 probands with idiopathic generalized epilepsy (IGE). BACKGROUND: In humans and in animal models, several lines of evidence implicate opioid receptors with seizures. The G118 allele of OPRM1 was associated with IAE (p = 0.019)....
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