Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease.

doi:10.1097/00041444-200209000-00006

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Article

Genetic polymorphisms and cerebrospinal fluid levels of tissue inhibitor of metalloproteinases 1 in sporadic Alzheimer's disease.

Psychiatric genetics - 1 Sept 2002

Wollmer M Axel, Papassotiropoulos Andreas, Streffer Johannes R, Grimaldi Luigi M E, Kapaki Elisabeth, Salani Giuliana, Paraskevas George P, Maddalena Alessia, de Quervain Dominique, Bieber Claudia, Umbricht Daniel, Lemke Ulrike, Bosshardt Simone, Degonda Nadia, Henke Katharina, Hegi Thomas, Jung Hans H, Pasch Thomas, Hock Christoph, Nitsch Roger M

Abstract excerpt

Tissue inhibitor of metalloproteinases 1 (TIMP-1) inhibits several proteinases including a disintegrin and metalloproteinase 10 (ADAM10), a major alpha-secretase that cleaves the beta-amyloid precursor protein within its amyloidogenic Abeta domain. The gene encoding TIMP-1 (TIMP 1) maps to the short arm of the X chromosome, in a region previously suggested as conferring genetic susceptibility for Alzheimer's...

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PMID: 12218659
DOI: 10.1097/00041444-200209000-00006

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ADAM10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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