Article
+331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer.
International journal of cancer - 1 Oct 2009
Kotsopoulos Joanne, Tworoger Shelley S, De Vivo Immaculata, DeVivo Immaculata, Hankinson Susan E, Hunter David J, Willett Walter C, Chen Wendy Y
Abstract excerpt
A functional promoter polymorphism in the progesterone receptor (PR) gene previously has been associated with an increased risk of postmenopausal breast cancer. Whether the relationship between genetic variation in PR and risk of breast cancer is modified by postmenopausal hormone (PMH) use is unknown. Thus, we conducted a case-control study nested within the prospective Nurses' Health Study to evaluate if the...
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