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Article

A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk.

Cancer research - 1 Sept 2003

De Vivo Immaculata, Hankinson Susan E, Colditz Graham A, Hunter David J

Abstract excerpt

Biological and epidemiological data suggest that progesterone has an important role in mammary tumorigenesis. Because the effects of progesterone require the progesterone receptor (PGR), which exists in two isoforms, PR-A and PR-B, we sought to determine whether the functional polymorphism, +331 G/A, which causes an increase in the expression of the hPR-B isoform, is related to breast cancer risk. Using a nested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14500352

Genes

PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk.PMID 14500352Read ↗

A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk.Semantic proximity Read ↗

+331G/A variant in the progesterone receptor gene, postmenopausal hormone use and risk of breast cancer.Semantic proximity Read ↗

Association of a progesterone receptor gene +331 G/A polymorphism with breast cancer risk: a meta-analysis.Semantic proximity Read ↗

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PGR +331 A/G and increased risk of epithelial ovarian cancer.Semantic proximity Read ↗

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GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism.Semantic proximity Read ↗

Genetic variation in the progesterone receptor gene and ovarian cancer risk.Semantic proximity Read ↗

No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis.Semantic proximity Read ↗

Prevalence of ERα-397 PvuII C/T, ERα-351 XbaI A/G and PGR PROGINS polymorphisms in Brazilian breast cancer-unaffected women.Semantic proximity Read ↗

Polymorphism in the progesterone receptor promoter gene in endometrial cancer alters its expressionSemantic proximity Read ↗

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