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Article

Progesterone receptor gene variants and risk of endometrial cancer.

Carcinogenesis - 1 Mar 2011

O'Mara Tracy A, Fahey Paul, Ferguson Kaltin, Marquart Louise, Lambrechts Diether, Despierre Evelyn, Vergote Ignace, Amant Frederic, Hall Per, Liu Jianjun, Czene Kamila, Rebbeck Timothy R, Ahmed Shahana, Dunning Alison M, Gregory Catherine S, Shah Mitul, Webb Penelope M, Spurdle Amanda B

Abstract excerpt

Prolonged excessive estrogen exposure unopposed by progesterone is widely accepted to be a risk factor for endometrial cancer development. The physiological function of progesterone is dependent upon the presence of its receptor [progesterone receptor (PGR)] and several studies have reported single nucleotide polymorphisms (SNPs) in the PGR gene to be associated with endometrial cancer risk. We sought to confirm...

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Identifiers

PMID: 21148628
DOI: 10.1093/carcin/bgq263
PMCID: PMC3105584

Genes

PGR

Provenance

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