Article
Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2002
De Pascalis Roberto, Iwahashi Makoto, Tamura Midori, Padlan Eduardo A, Gonzales Noreen R, Santos Ameurfina D, Giuliano Mariateresa, Schuck Peter, Schlom Jeffrey, Kashmiri Syed V S
Abstract excerpt
Murine mAb COL-1 reacts with carcinoembryonic Ag (CEA), expressed on a wide range of human carcinomas. In preclinical studies in animals and clinical trials in patients, murine COL-1 showed excellent tumor localization. To circumvent the problem of immunogenicity of the murine Ab in patients, a humanized COL-1 (HuCOL-1) was generated by grafting the complementarity-determining regions (CDRs) of COL-1 onto the...
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