Article
Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.
Journal of molecular biology - 25 Feb 2000
Beiboer S H, Reurs A, Roovers R C, Arends J W, Whitelegg N R, Rees A R, Hoogenboom H R
Abstract excerpt
Antibody engineering provides an excellent tool for the generation of human immunotherapeutics for the targeted treatment of solid tumours. We have engineered and selected a completely human antibody to epithelial glycoprotein-2 (EGP-2), a transmembrane glycoprotein present on virtually all human...
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