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Article

Effects of humanization and gene shuffling on immunogenicity and antigen binding of anti-tag-72 single-chain Fvs

1 Jan 2001

Abstract excerpt

One major constraint in the clinical application of murine monoclonal antibodies (MAbs) is the development of a human antimurine antibody response. The immunogenicity of MAbs can be minimized by replacing nonhuman regions with corresponding human sequences. The studies reported in our article were undertaken to analyze the immunoreactivity and the immunogenicity of the CC49 single-chain antibody fragments...

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Share to Monoclonal and Polyclonal Antibodies Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11745468
DOI: 10.1002/ijc.1523

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