Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene Promoter

1 Nov 2002

Abstract excerpt

Increased placental leptin has been demonstrated in preeclampsia, a pregnancy disorder associated with placental hypoxia. This suggests that leptin gene expression is enhanced in response to oxygen deficiency in this organ. In support of this hypothesis, we have previously shown that hypoxia activates the leptin promoter in trophoblast-derived BeWo cells. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related molecular mechanisms research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12215445
DOI: 10.1074/jbc.m206775200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-inducible Factor 1 Transactivates the Human Leptin Gene PromoterPMID 12215445Read ↗

Induction of glucose transporter 1 expression through hypoxia-inducible factor 1α under hypoxic conditions in trophoblast-derived cellsSemantic proximity Read ↗

Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)Semantic proximity Read ↗

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1αSemantic proximity Read ↗

Augmentation of leptin and hypoxia-inducible factor 1α mRNAs in the pre-eclamptic placentaSemantic proximity Read ↗

Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1Semantic proximity Read ↗

Human Placental Hypoxia-Inducible Factor-1α Expression Correlates with Clinical Outcomes in Chronic Hypoxia in VivoSemantic proximity Read ↗

Identification of a Placental Enhancer for the Human Leptin GeneSemantic proximity Read ↗

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.Semantic proximity Read ↗

Up-Regulation ofc-metProtooncogene Product Expression through Hypoxia-Inducible Factor-1α Is Involved in Trophoblast Invasion under Low-Oxygen TensionSemantic proximity Read ↗

The gene encoding human retinoic acid-receptor-related orphan receptor α is a target for hypoxia-inducible factor 1Semantic proximity Read ↗

HIF-dependent induction of adenosine A2B receptor in hypoxia.Semantic proximity Read ↗

Human umbilical cord and fetal membranes co-express leptin and its receptor genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.