Article
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
The Journal of biological chemistry - 3 Apr 1998
Wood S M, Wiesener M S, Yeates K M, Okada N, Pugh C W, Maxwell P H, Ratcliffe P J
Abstract excerpt
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control have revealed the existence of hypoxia-responsive elements (HREs) in the cis-acting sequences of several of these genes. These sequences generally contain one or more bind...
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